Morphix CoT DNA: Silence the Repetitive Noise

The Gold Standard for Specificity in Genomic Assays

code	Name	Unit/size	price
MRX-CoT1-01	CoT1-01 DNA	1.1 mg/ml, 1ml	€725
MRX-CoT1-10	CoT1-10 DNA	1.1mg/ml, 10ml	€6500

Stop wasting data on background noise. Morphix CoT DNA is the essential shield against non-specific binding in your most critical hybridization experiments.

Product Overview: Clean Data, Clear Results

The ultimate frustration in genomics is background noise from highly repetitive DNA sequences (like Alu and LINE elements) contaminating your crucial signals. When cross-hybridization runs rampant, your signal is lost, your accuracy is compromised, and your time is wasted.

Introducing Morphix CoT DNA, the newest essential in our Morphix line. This premium-grade, gold-standard Co t-1 DNA is engineered specifically to eliminate that noise, bringing clarity and confidence back to your most complex work.

It is simply the most effective way to ensure that your labeled probes and primers bind only to the specific, unique regions of interest.

Key Applications & Benefits

Benefit
Fluorescence In Situ Hybridization (FISH)	Eliminates non-specific probe binding to repetitive regions on chromosomes, leading to sharper signals and easier interpretation.
Array Comparative Genomic Hybridization (aCGH)	Dramatically reduces cross-hybridization to achieve clean, high-resolution data and minimize false positives.
NGS Hybrid-Capture	Essential for efficient target enrichment by blocking non-specific binding during hybridization steps in Next-Generation Sequencing workflows.
General Hybridization Assays	Improves the sensitivity and accuracy of any experiment involving nucleic acid probes or arrays.

How Morphix CoT DNA Works

Morphix CoT DNA is prepared from human placental DNA that has been sheared and reannealed to enrich for highly repetitive sequences such as the Alu and Kpn family members.

When added to your hybridization reaction, the CoT DNA acts as a precision shield:

Competitive Binding: The CoT DNA strands bind competitively to the corresponding highly repetitive regions (SINEs and LINEs) on your target genomic DNA.
Blocking: This action effectively blocks these non-specific binding sites.
Ultimate Specificity: This ensures that your valuable labeled probes and primers are only free to bind to the unique target sequences you are interested in, preventing cross-hybridization and dramatically lowering your background signal.

Technical Specifications

Source	Human Placental DNA
Preparation	Sheared, denatured, and reannealed to enrich for repetitive elements
Size Range	Predominantly 50 to 300 bp
Target	Blocks highly repetitive genomic elements (Alu, LINE, Kpn)
Quality	High-purity, rigorously prepared for batch-to-batch consistency
Format	Ready-to-use solution

Morphix: Reliable Essentials for Your Lab.

Morphix CoT DNA is the essential shield against non-specific binding, bringing ultimate specificity and clarity to your genomic data. Trust the Morphix line for components you never have to troubleshoot.